|A randomised controlled trial of guided self-help for depression for autistic adults
|A study to see if Air Filtration prevents winter coughs, colds, flue, and COVID-19 in care homes (AFRI-c)
Aspirin after hospitalisation with Pneumonia to prevent cardiovascular Events randomised Controlled Trial
|Adalimumab vs placebo as add-on to Standard Therapy for autoimmune Uveitis: Tolerability, Effectiveness and cost-effectiveness: a randomized controlled trial
|ATHENA: AmiTritypline for the prevention of post-HErpetic NeuralgiA
|Gastric Bypass, adjustable gastric Banding or Sleeve gastrectomy surgery to treat severe and complex obesity: a multi-centre randomised controlled trial
|Continuous rectus sheath Analgesia in eMErgency LaparOTomy, a multi centre, randomised sham-controlled trial of rectus sheath catheter-delivered local anaesthetic infusion compared with usual care in patients undergoing emergency bowel surgery
|Cluster randomised trial of PSA testing for Prostate cancer
|UK Cohort study to Investigate the prevention of Parastomal HERnia
|Carbon dioxide insufflation and brain protection during open-heart surgery
|Combining Influenza and COVID-19 vaccination (ComFluCOV) study
|COMITED is an NIHR-HTA funded randomised controlled trial to find out whether a collapsed lung (pneumothorax) due to injury (trauma) can be safely and effectively treated without immediately inserting a tube into the chest (chest drain). 750 adult patients with a collapsed lung after trauma will be recruited from (at least) 25 hospital Emergency Departments in the UK.
|We aim to understand whether treating people with a lung collapse (pneumothorax) without inserting a needle into the chest is safe and effective.
|In patients with heart failure with reduced ejection fraction (HFrEF), is the addition of Coenzyme Q10 (CoQ10) to usual care clinically and cost-effective?
|EPIToPE: Evaluationg the Population Impact of Hepatitis C Direct Acting Antiviral Treatment as Prevention for People Who Inject Drugs
|Effectiveness, cost effectiveness and safety of gabapentin versus placebo as an adjunct to multimodal pain regimens in surgical patients: A placebo controlled randomised controlled trial with blinding
|H4RT is a non-blinded Randomised Controlled Trial comparing the clinical and cost-effectiveness of high-volume HDF compared with high-flux HD in the treatment of end stage kidney disease.
|Hypobaric Oxygen during cardiopulmonary bypass to reduce gaseous Micro-Emboli during cardiac surgery: a randomised controlled trial.
|Effectiveness and cost-effectiveness of INSPIRatory musclE training (IMT) for reducing postoperative pulmonary complications (PPC): a sham-controlled randomised controlled trial (RCT)
|INTERACT is a 6-year research programme to design and evaluate integrated therapist and online CBT for depression in primary care
|Mesothelioma and Radical Surgery 2: a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma
|A multicentre cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of an environmental nutrition and physical activity intervention in nurseries (Nutrition and Physical Activity Self Assessment for Child Care)
|Outcome Monitoring After Cardiac Surgery
|The clinical and cost-effectiveness of elective primary total knee replacement with PAtellar Resurfacing compared to selective patellar resurfacing. A pragmatic multicentre randomised controlled Trial with blinding (PART)
|Aims to investigate whether taking the medication Pravastatin reduces the number of babies born too early (preterm i.e., before 37 weeks of pregnancy), in pregnant people who are at medium to high risk of preterm birth. The trial also aims to understand how Pravastatin prevents preterm birth
|Prepare for Kidney Care
|The Prepare Multi-Morbid Older People for End-Stage Kidney Disease Trial
|Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: Propofol cardioplegia for myocardial protection randomised controlled trial
|Evaluating the effectiveness of treatments for clinically localised prostate cancer
|PURSUIT: Proper Understanding of Recurrent Stress Urinary Incontinence Treatment in women: a randomised controlled trial of endoscopic and surgical treatment.
|Radiofrequency denervation for chronic and moderate to severe low back pain
|Multi-modality local consolidative treatment versus conventional care of advanced lung cancer after first line systemic anti-cancer treatment: a multi-centre randomised controlled trial with an internal pilot
|Use of a rapid microbiological Point-of-Care-Test (POCTRM) can reduce same-day antibiotic prescribing for patients presenting to their GP with a respiratory tract infection. surgery
|Impact of feedback from Real-time, electronic symptom monitoring on post-discharge recOvery after Surgery for oEsophago-gastric cancer: a multi-centre randomised controlled trial. surgery
|The Randomised Evaluation of early topical Lidocaine patches in elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trial
|Reaching Everyone Programme of Research On Violence in diverse Domestic Environments (Centre for Academic Primary Care/Reprovide)
|A Randomised Controlled Trial of Scaffold InSertion and MIcrofracture Compared to Microfracture Alone for the Treatment of Chondral or Osteochondral Defects of the Knee
|SerTRaline for AnxieTy in adults with a diagnosis of Autism
|A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with magnetic resonance cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones
|Trial of food allergy (IgE) tests for eczema relief
|Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment of Methods (UPSTREAM) for diagnosis and management of bladder outlet obstruction in men
|Study looking at the safety, as well as the immune responses, when giving the currently approved shingles vaccine (Shingrix) at the same time as either the recommended COVID-19 booster or the influenza (flu) vaccines from the 2023/2024 flu season programme